Genetic variants related to age-related macular degeneration (AMD) point to the underlying
biology of the disease and can become therapeutic targets. A set of these markers known to be
associated with AMD, along with knowledge of other non-genetic predictors (including age, sex,
education, BMI, and smoking history) can be used to calculate a score associated with an
individual probability of progressing to advanced disease. These probabilities can range from
very low to very high, depending on the combination of individual risk factors. This knowledge
can be useful for identifying high-risk individuals for lifestyle changes related to modifiable risk
factors, selecting high-risk subjects for participation in clinical trials, and prescribing appropriate
Risk score models may also enhance patient management by clinicians, including advising on
preventative measures, frequency of monitoring, assisting with the differential diagnosis of
AMD and its subtypes, and possible diagnosis of treatable neovascular disease at an earlier stage.
The risk calculator could also potentially assist in the development of personalized medicine
approaches for AMD.
A risk prediction model for progression of AMD (rPPMD) Risk Calculator is provided to
illustrate the utility of these predictive analytics. The rPPMD Calculator aims to facilitate and
support clinical decision making, both on an individual and collaborative basis. Click on the
button below to go to the rPPMD Risk Calculator.
Supported by Grants RO1-EY11309 and RO1-EY022445 from the
National Institutes of Health, Bethesda, Maryland, United States;
the Massachusetts Lions Eye Research Fund, Inc., New Bedford,
Massachusetts, United States; unrestricted grants from Research to
Prevent Blindness, Inc., New York, New York, United States;
Foundation Fighting Blindness, Columbia, Maryland, United States;
the American Macular Degeneration Foundation, Northampton,
Massachusetts, United States; and the Age-Related Macular
Degeneration Research Fund, Ophthalmic Epidemiology and
Genetics Service, Tufts Medical Center, Tufts University School of
Medicine, Boston, Massachusetts, United States. The authors alone
are responsible for the content and writing of the paper.
Disclosure: J.M. Seddon, P; R.E. Silver, None; M. Kwong, None;
B. Rosner, None
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